To keep the research at the Hanson Institute at the cutting edge, and to enhance our ability to find new solutions, treatments and therapies, our Laboratories need to upgrade and update their equipment they use.
If you are looking for a different way to support Medical Research, you could consider giving a gift from the equipment wish list below. You can choose a specific item of equipment, or put your gift towards any of the equipment needs.
The Researchers at the Hanson Institute are closely affiliated with the Royal Adelaide Hospital; this strong bond ensures a close alignment of research with the needs to improve medical practice through translational research.
To donate, either click on the equipment image to go to our online donation page, or download and complete an Equipment Donation Form and send it to us at:
Royal Adelaide Hospital Research Fund
Adelaide South Australia 5000
Your purchase and donation of any of the following equipment would make a huge impact in allowing research to move forward and assist our researchers to achieve their goals.
COUNTESS AUTOMATED CELL COUNTER
A quick and accurate measure of cell count and viability is of vital importance in cellular therapies where certain cell numbers are required for transplantation.
This cell counter is designed to measure cell count and viability (live, dead, and total cells) accurately and precisely.
The cell counter helps eliminate subjectivity, minimises human error inherent in manual counting and provides results in less than 30 seconds.
Required for an ongoing project in the Cancer Therapeutics Laboratory, who are developing promising new anticancer drugs that kill cancer cells at very low doses.
We are generating additional chemical derivatives of these lead compounds and the Fluostar Omega is required to enable high throughput testing.
This instrument will help determine the most effective compounds.
This cell analyser enables very sensitive detection and analysis of leukaemia cells in blood.
This cell analyser will allow the Molecular Signalling Laboratory to very sensitively determine the ability of new anti-cancer agents to reduce both total leukaemic burden, and most importantly, eradicate the low abundance, but highly chemotherapeutic-resistant leukaemia initiating cells that are often responsible for patient relapse.
A number of commercially-funded studies within the Mucositis Research Group has meant a large number of tissue samples requiring long-term storage (-80C).
We are rapidly running out of room in our current freezer and wish to acquire a large chest freezer for storage of the samples.
The Mucositis Research Group investigates gut damage caused by anti-cancer treatments. They have a high throughput of tissue samples requiring fine sectioning for staining and analysis.
The lab currently uses a microtome in an adjunct laboratory where many bookings for the equipment result in delays to some of their experiments.
The SA Cancer Research Biobank provides a state-wide resource for scientists conducting research into blood cell cancers and disorders. The Biobankcollects blood and bone marrow specimens from consenting patients from the four major public hospitals in SA, including the Royal Adelaide Hospital.
The specimens are processed and stored within a dedicated laboratory located on the RAH campus, for release to researchers investigating the causes, progression and treatment outcomes of cancer.
A centrifuge is required to separate the blood cell components from liquid components.This equipment will benefit a large number of biomedical researchers on campus and facilitate a wide range of research projects in cancer.
The long term cryogenic storage of blood and bone marrow cells at the SA Cancer Research Biobank.
Used by the SA Institute of Ophthalmology at the RAH to assess electrical output of the retina as a measurement of ocular function.
Vision researchers use the equipment to determine functional level of vision in eyes of normal and experimentally blind animal subjects.
To concentrate and separate ocular tissue and cell extracts.
Used by basic science and clinical vision researchers in the SA Institute of Ophthalmology to assess molecular mechanisms of blinding diseases.
A cryostat is used by researchers in the Clinical Centre for Experimental Therapeutics (Renal Unit) lab to cut tissue sections for microscopic analysis. This allows researchers to investigate patient and research samples providing insight into disease processes and measuring treatment outcomes.
This cryostat is state of the art and has added safety features for installing and removing the blade.
Approx Cost: $65,000-70,000
This cabinet provides a clean and sterile environment allowing the culture of many different cell types.
It also protects the researcher from hazardous material being manipulated in the cabinet. It is a critical piece of equipment with a high daily usage rate within the Clinical Centre for Experimental Therapeutics laboratory.
Currently, researchers at the Royal Adelaide Hospital, the Hanson Institute and collaborative partners require the ability to image tissue specimens in non-destructive way. The Skyscan 1272 Micro-CT scanner is a state-of-the-art machine which would allow us to image and measure the internal features of numerous tissues. It is a high resolution, high throughput scanner which does not damage the specimen. A wide range of applications could use this technology, including oncology (where we would look for tumour development, the effects of drugs on tumours and detection of metastases), cardiovascular research (where we could inject contrast agents to image blood vessels) and musculoskeletal research (where we could image of bone to identify micro-fractures).
Multiple Science disciplines require the need to perform micro-computed tomography (micro-CT) of specimens in order to image and quantify specimens at a sufficiently high resolution as well as allow for high throughput scanning and without destruction of the specimen. Currently, while it is possible to perform micro-CT in the state, there is not the ability to perform adequately high resolution scans that can capture relatively large specimens within the field of view and that can be used by any minimally trained user.
The Skyscan 1272 Micro-CT system can nondestructively visualize virtual slices through objects, using newly developed 16Mp and 11Mp X-ray detectors. Due to phase-contrast enhancement, object details as small as 0.35um can be detected.
Approx Cost: $400,000
The Skyscan 1272 system would be used by many groups, including:
The Gastroenterology Research Laboratory, headed by Associate Professor Andrew Ruszkiewicz, investigates gastrointestinal cancer, particularly in bowel cancer and malignancies of the oesophagus, pancreas and stomach.
The research conducted by his group concentrates particularly on early detection and improvement in treatment of bowel cancer which is the second most common cause of cancer-related death in Australia.
The DAKO Omnis enables automationthat ensures a faster turnaround time and delivers consistent quality and optimal results. It delivers a high throughput, including the possibility of overnight runs, plus full traceability of patient cases through onboard and workstation software.
Approx Cost: $180,000
The Leica laser microdissection system will enable the Gastroenterology Research Laboratory to deliver contact and contamination-free dissection and specimen collection simply by gravity.
The system guides a laser beam via optics for the highest cutting speed and precision of the laser.
Research staff at the Adelaide Centre for Spinal Research, spinal cord injury research and Orthopaedics and Trauma Research will use this equipment to automatically print labels onto histology slides.
The printer will greatly improve the throughput of the histology laboratory, enabling scientists and research assistants to spend valuable time on other research activities.
Polarized light and fluorescence microscopy are used to investigate microstructural changes in cartilage tissues, intervertebral discs and tendons which are caused by disease and injury.
This microscope upgrade will enhance and accelerate current studies seeking to understand the association between scoliosis and structural changes in the intervertebral disc and interactions between sutures and tendon fibres in failed rotator cuff repairs.
Osteoporosis is a condition of decreased bone mass and bone quality which affects over one million people in Australia and places them at high risk of fracture from minor trauma.
Spinal cord injured patients and those with limited mobility are at particular risk of bone disease. This system is a low-radiation and non-invasive method for accurately quantifying changes in bone and muscle quality.
Researchers in the Adelaide Centre for Spinal Research will use this to measure bone and muscle quality and geometry in adults and children for longitudinal studies of the effects of disease, disability and treatments on bone and muscle health.
Mechanical testing machines are used to characterise the mechanical behaviour of biological tissues, to help Adelaide Centre for Spinal Research researchers understand the disease processes and injury mechanisms affecting the musculoskeletal system.
Diseases and injuries of the musculoskeletal system can significantly impact an individual’s quality of life. Understanding the mechanical function of tissues is vital to improving prevention and treatment strategies.
Bones and other tissues of the musculoskeletal system are typically fractured in impact events that occur quickly and with high forces.
Determining the tolerance of bones and other tissues leads to improvements in the design of injury prevention devices (e.g. airbags in cars).
This equipment will allow researchers at the Adelaide Centre for Spinal Research, spinal cord injury research, and orthopaedics and trauma research to measure forces and torques resulting in fracture at realistic impact speeds for injury biomechanics research.
In addition to high speed spinning capabilities, this centrifuge features a built-in refrigerator that allows temperature adjustment between -9°C to 40°C.
The ability to spin blood samples at low temperatures with this equipment is crucial as it helps preserve cell and particle integrity in some sensitive procedures.
The Myelodysplastic Syndrome Research Laboratory is currently involved projects including mutational screening, gene expression studies and a comprehensive assessment of elderly patients in clinics.
A microcentrifuge is different from the usual bench top centrifuge as it allows small amount of samples to be spun at high speeds.The cooling capability is crucial as it maintains sample integrity and protects sensitive samples from heat degeneration.
The MDS Research Group will use this equipment to help gain a better understanding of MDS, and improve clinical outcomes by developing better therapies for the disease
Centrifugation of small samples is important for many biological applications, such as pelleting nucleic acids for downstream application such as gene sequencing, or isolating proteins from solutions for electrophoresis.
Gel electrophoresis is the process of separating particles contained within a gel via three-dimensional electric field. Particles that are commonly separated by this process include DNA and proteins previously extracted from cells.
The results will be stained with special dyes to allow visualisation of separated material. This process is extremely important as it allows DNA and proteins to be visualised. Gel electrophoresis is by far the quickest way to visualise DNA and the most common method of visualising proteins, which is why it is an integral item for the Myelodysplastic Syndrome Research Group.
The roller mixer operates between 10-60 rpm, which is an ideal speed for mixing blood samples, viscous substances and liquid-solid suspensions where minimal aeration is required.
In addition to sample mixing, the roller mixer can also be used in aiding the de-frosting of frozen samples for the MDS Research Group.
Used by both research and diagnostic groups at the Australian Cancer Research Foundation (ACRF) Genomics Facility to uncover disease causing mutations, and detect cancer that leads to personalised therapy for cancer patients.
This sequencing equipment is capable of sequencing whole genomes, exomes and transcriptomes.
Automates sample (DNA and RNA) preparation for Illumina sequencing
The equipment will be used in the Genomics Facility to prepare cancer samples for the sequencers above to uncover disease causing mutations.
The same preparation is currently performed manually which is labour intensive and slow.
FLUIDIGM FC1 CYCLER
Used by research groups in the the Genomics Facility to assess gene expression, genotyping or produce amplicons for sequencing from cancer samples.
Used by research and diagnostic groups at the ACRF Genomics Facility to assess gene expression from cancer samples.
Used by researhcers using the ACRF Genomics Facility to study biologic and genetic properties of different cell types, which is is particularly useful in cancer studies where tumour cells are mixed with normal cells that can mask their genomic abnormalities and growth characteristics.
The equipment allows purification of different cell types.
The roved Tissue-Tek offers the Gastroenterology Research Laboratory a more reliable and simplified operation.
This equipment provides more efficient processing using a redesigned control panel for easy monitoring of the system status and has several preventive functions to protect against unexpected situations.
Approx Cost: $49,000
A vortex mixer is used for thorough mixing of a variety of solute preparations for cells, protein, RNA and viral work for biochemical experiments. It mixes material at high speeds of up 2700 RPM.
The Lung Research Group will use this equipment for cell culture, protein and RNA extraction and general laboratory experiments.
Approx Cost: $350
AKTA Pure 25M1 analytical liquid chromatography (LC) system
The Cytokine Receptor Laboratory studies the actions of protein hormones (cytokines) that regulate the function of blood cells and are involved in diseases such as leukaemia and rheumatoid arthritis. We need a new LC system to assist in these studies by measuring the amount and purity of protein samples and to assess their molecular interactions. Access to this machine will also benefit a number of other groups at the Hanson Institute.
Approx Cost: $90,000
Seahorse XFp Metabolic Analyser
This analyser will be used primarily in the Acute Leukaemia Research Laboratory, but can be used many other areas of research as well including drug discovery and familial disease tracking to name a couple. This is a machine will allow us to remain at the cutting edge of research and currently there are no machines capable of carrying out these assays in South Australia, at any research institute or university.
It is well known that cancer cells alter how they produce their energy, a trait taken advantage of in order to visualise where a tumour is located in the body. A cell in the body has 4 main ways of producing energy. The XFp analyser allows for assaying cancer cells and ascertaining which energy pathway is used and to what extent.
With this machine we are able to determine with great accuracy whether cells use their mitochondria, lipid breakdown, amino acid breakdown or glycolysis. This is most critical in cancer research as it will allow us to identify how cancer cells keep their energy stores up and this will then facilitate the discovery of therapeutic agents that target this unique characteristic of cancers alone.
Approx Cost: $100,000