Professor Sharad Kumar
Our research focus is on fundamental cancer biology and the molecular exploration of human diseases through the study of cell death and ubiquitination. Millions of cells in the human body die every minute by programmed cell death (PCD), which plays a key role in cell and tissue homeostasis and too little or too much of it can lead to many human diseases including cancer. Given its essential role in normal functioning of the body, deciphering the mechanisms that mediate cell death is essential for understanding disease processes and to design effective treatment strategies.
Ubiquitination is a common type of protein modification that is involved in the disposal of old and/or damaged proteins. As such it plays a major role in cell growth, renewal and cancer, among other regulatory pathways. It is thus necessary to study and understand this process at a fundamental level.
To support the Molecular Regulation Laboratory, please contact the Royal Adelaide Hospital Research Fund.